Testicular Cancer Trials

Many cancers of the testicles and urinary tract are rare diseases; these are diseases that affect less than 200,000 people in the United States. It can be hard to study treatments for these diseases. One combination of drugs enfortumab vedotin (EV, a type of targeted therapy) and pembrolizumab (Keytruda, a type of immunotherapy), has already been approved to treat some urinary cancers. Researchers want to see if they can help people with other types of testicle and urinary cancers. The objective of this study is to test EV, with or without pembrolizumab, in patients with rarer cancers of the testicles or urinary tract. This study has 2 treatment arms: Arm A: Enfortumab vedotin (EV) EV is administered intravenously (IV) at 1.25 mg/kg. Dosing schedule will be provided by treatment team. Arm B: Pembrolizumab + Enfortumab vedotin (EV) Pembrolizumab is administered IV at 200 mg on day 1 of each 21-day cycle. EV is administered intravenously (IV) at 1.25 mg/kg. Dosing schedule will be provided by treatment team.

The purpose of this study is to determine whether accelerated BEP chemotherapy is more effective than standard BEP chemotherapy in males with intermediate and poor-risk metastatic germ cell tumors (including testicular cancer). Bleomycin, Etoposide, Cisplatin (BEP) remains standard first line chemotherapy for intermediate- and poor-risk metastatic germ cell tumours (GCTs). Cure rates are over 90% for good-risk disease, 85% with intermediate-risk, and about 70% for poor-risk disease. Previous strategies to improve first-line chemotherapy have failed to improve cure rates and were more toxic than BEP. New strategies are needed for patients with intermediate and poor-risk disease. BEP is accelerated by cycling Cisplatin and etoposide. The Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP) is conducting this trial comparing accelerated BEP with standard BEP.

This phase III trial studies how well active surveillance, bleomycin, carboplatin, etoposide, or cisplatin (all types of chemotherapy) work in treating pediatric and adult patients with germ cell tumors (including testicular cancer). Active surveillance may help doctors to monitor subjects with low risk germ cell tumors after their tumor is removed. Drugs used in chemotherapy, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.

This research trial studies the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care. Patients undergo medical data review to create a Childhood Cancer Registry. Patients also undergo collection of bio-specimen samples (e.g., tissue, blood, bone marrow, plasma, serum, buccal cells, saliva, cerebrospinal fluid, or urine). This is NOT a treatment study.